Venous Limb Gangrene (Last Updated - 3/6/2005)

-seen in pts. on warfarin (coumadin) tx who are HIT-Ab positive
-if pts. are known to be HIT-Ab positive --> LMWH's & Warfarin (Coumadin) are to be AVOIDED due to cross-reactivity w/ heparin

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References:

Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.